JANUVIA

Diabete / Januvia / 35 pilules de Brand Januvia (Sitagliptin Phosphate) * 50 mg. Laboratoire: Merck Sharp 115.17$ Acheter

GENERIC NAME: Sitagliptin Phosphate

BRAND NAME: Januvia

How does it work?

Januvia tablets contain the active ingredient sitagliptin, which is a type of medicine called a dipeptidyl peptidase 4 (DPP-4) inhibitor. It is used to treat people with type 2 or non-insulin dependent diabetes (NIDDM).

Sitagliptin works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar (glucose) levels.

GLP-1 and GIP have four main actions that help to control blood glucose.

Firstly, they stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood. (Insulin is the main hormone responsible for controlling sugar levels in the blood. It causes cells in the body to remove sugar from the blood.)

GLP-1 also reduces the production of glucagon. (Glucagon is a hormone that normally increases glucose production by the liver.)

GLP-1 and GIP also reduce the rate at which food passes from the stomach into the intestines, which slows down the absorption of glucose from the gut into the bloodstream. Finally, they act on the brain to cause a feeling of fullness that reduces further food intake.

GLP-1 and GIP are normally broken down by an enzyme in the body called dipeptidyl peptidase 4. Sitaglipin works by binding to this enzyme and preventing it from breaking down the GLP-1 and GIP. This increases the levels of these hormones in the body and so increases their effect on controlling blood sugar.

Januvia is used for people with type 2 diabetes whose blood sugar is not sufficiently controlled by other antidiabetic medicines. It can be added to treatment with metformin, a sulphonylurea, for example gliclazide, or another type of antidiabetic medicine known as a thiazolidinedione, for example pioglitazone or rosiglitazone.

Januvia 100mg tablet is taken once daily, with or without food. If you forget to take a tablet then it can be taken as soon as you remember. However, two tablets should not be taken on the same day.

What is it used for?

• Type 2 diabetes (non-insulin dependent diabetes).

• Decreased kidney function.
• People over 75 years of age.

• Type 1 diabetes.
• Diabetic ketoacidosis.
• This medicine is not recommended for people receiving dialysis or who have moderate to severe kidney disease.
• Pregnancy.
• Breastfeeding.
• This medicine is not recommended for children and adolescents under 18 years of age because it has not been studied in this age group.

• The safety of this medicine for use during pregnancy has not been established. It should not be used during pregnancy. Diabetes mellitus is usually controlled using insulin during pregnancy, because this provides a more stable control of blood sugar. If you get pregnant while taking this medicine, or are planning a pregnancy, you should seek medical advice from your doctor.
• It is not known if this medicine passes into breast milk. The manufacturer states that it should not be used by breastfeeding mothers. Seek medical advice from your doctor.

• Nausea.
• Excess gas in the stomach and intestines (flatulence).
• Low blood glucose levels (hypoglycaemia).
• Headache.
• Swelling of feet or ankles (peripheral oedema).
• Inflammation of the nose and throat, causing a blocked or runny nose and sore throat (nasopharyngitis).
• Upper respiratory tract infection.
• Blocked nose.
• Sore throat.
• Pain in the arms or legs.
• Osteoarthritis.
• Constipation.
• Abdominal pain.
• Loss of appetite.
• Diarrhoea.
• Weight loss.
• Dizziness.
• Drowsiness.
  

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Sitagliptin may cause a small increase in the amount of digoxin in the blood when both medicines are being taken together. If you are taking digoxin, your doctor may want you to have regular blood tests to monitor the amount of digoxin in your blood after you start treatment with this medicine.

Warning!

• Hypoglycaemia (low blood glucose) has been commonly reported when this medicine is used in combination with sulphonylurea medicines, eg gliclazide or glibenclamide, or with glitazone medicines, such as rosiglitazone or pioglitazone. Symptoms of hypoglycaemia usually occur suddenly and may include cold sweats, cool pale skin, tremor, anxious feeling, unusual tiredness or weakness, confusion, difficulty in concentration, excessive hunger, temporary vision changes, headache, nausea and palpitations. You should talk to your doctor about this and make sure you know what to do if you experience these symptoms.
• Your ability to concentrate or react may be reduced if you have low blood sugar, and this can cause problems driving or operating machinery. You should take precautions to avoid low blood sugar when driving - discuss this with your doctor. This medicine may also uncommonly cause dizziness or drowsiness. If affected you should take care driving or operating machinery.